대한핵의학회지 (1967년~2009년)
Nucl Med Mol Imaging 2008;42(5)347~353
일측 뇌경색 환자에서 반대측 뇌의 보상성 뇌관류 증가에 대한 SPM 분석
(Ipsilateral Cerebral and Contralateral Cerebellar Hyperperfusion in Patients with Unilateral Cerebral Infarction; SPM Analysis)
Author 홍선표1, 윤준기1, 최봉회1, 주인수2, 윤석남1,
Sun-Pyo Hong, M.D.1, Joon-Kee Yoon, M.D., PhD.1, Bong-Hoi Choi, M.D.1, In Soo Joo, M.D., PhD.2, and Seok-Nam Yoon, M.D., PhD.1
Affiliation 아주대학교 의과대학 핵의학교실1, 신경과학교실2
Departments of 1Nuclear Medicine and Molecular Imaging, and 2Neurology, Ajou University School of Medicine, Suwon, Korea
Abstract

Purpose: Cortical reorganization has an important role in the recovery of stroke. We analyzed the compensatory cerebral and cerebellar perfusion change in patients with unilateral cerebral infarction using statistical parametric mapping (SPM). Materials and Methods: Fifty seven 99mTc-Ethylene Cystein Diethylester (ECD) cerebral perfusion SPECT images of 57 patients (male/female=38/19, mean age=56¡¾17 years) with unilateral cerebral infarction were evaluated retrospectively. Patients were divided into subgroups according to the location (left, right) and the onset (acute, chronic) of infarction. Each subgroup was compared with normal controls (male/female=11/1, mean age =36¡¾10 years) in a voxel-by-voxel manner (two sample t-test, p<0.001) using SPM. Results: All 4 subgroups showed hyperperfusion in the ipsilateral cerebral cortex, but not in the contralateral cerebral cortex. Chronic left and right infarction groups revealed hyperperfusion in the ipsilateral primary sensorimotor cortex, meanwhile, acute subgroups did not. Contralateral cerebellar hyperperfusion was also demonstrated in the chronic left infarction group. Conclusion: Using 99mTc-ECD SPECT, we observed ipsilateral cerebral and contralateral cerebeller hyperperfusion in patients with cerebral infarction. However, whether these findings are related to the recovery of cerebral functions should be further evaluated. (Nucl Med Mol Imaging 2008;42(5):347-353)

Keyword 99mTc-ECD perfusion SPECT, cerebral infarction, statistical parametric mapping, functional recovery
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