PPT 슬라이드
Splenic accumulation of Tc-99m - MDP in a transfusion dependent patient with chornic myelogenous leukemia
J Nucl Med 1990; 31: 1552-1553
37-yr-old female, CML diagnosed 15 yr prior to admission, accelerated phase, BMT.
magaged with hydroxyurea , interferon and transfusion of purified red blood cells.
Some of the mechanism proposed to explain accumulation of bone-seeking agents in spleen
: infarction, acidosis and hypoxia with calcification, excess iron deposition, increased local phosphatase activity, tumor avidity.
Significant deposition of hemosiderin in the spleen: common feature.
locally elevated concentration of iron, secondary to frequent transfusion and increased RBC sequestration.