원저 : 99mTc - HMPAO 뇌혈류 SPECT 영상의 부위별 체적 혈류 평가에 관한 기초 연구 ( A Preliminary Quantification of 99mTc - HMPAO Brain SPECT Images for Assessment of Volumetric Regional Cerebral Blood Flow ) () |
Author |
곽철은(Cheol Eun Kwark),박석건(Seok Gun Park),양형인(Hyung In Yang),최창운(Chang Woon Choi),이경한(Kyung Han Lee),이동수(Dong Soo Lee),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh), |
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Affiliation |
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Abstract |
The quantitative methods for the assessment of the
cerebral blood flow using Tc-99m- HMPAO brain SPECT
utilize the measured count distribution in some
specific reconstructed tomographic slice or in
algebraic summation of a few neighboring slices, rather
than the true volumetric distribution, to estimate the
relative regional cerebral blood flow, and consequently
produce the biased estimates of the true regional
cerebral blood flow. This kind of biases are thought to
originate mainly from the arbitrarily irregular shape
of the cerebral region of interest(ROI) which are
analyzed. In this study, a semi-automated method for
the direct quantification of the volumetric regional
cerebral blood flow estimate is proposed, and the
results are compared to those calculated by the
previous planar approaches. Bias factors due to the
partial volume effect and the uncertainty in ROI
determination are not considered presently for the
methodological comparison of planar/volumetric
assessment protocol. |
Keyword |
Cerebral blood flow, 99mTc-HMPAO brain SPECT , Volumetric estirnation, Planar assessment, Quantification |
Full text Article |
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