원저 : 류마티스 관절염 치료용 디스프로슘-165금속 응집입자 ( 165Dy-MA ) 의 제조에 관한 연구 ( Studies on Preparation of Dysprosium - 165 Metallic Macroaggregates for the Treatment of Rheumatoid Arthritis ) () |
Author |
박경배(Kyung Bae Park),김재록(Jae Rok Kim), |
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Affiliation |
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Abstract |
Irradiation of 20mg of natural Dy(NO3)3 in a neutron
flux of 2*10(13)n/cm2 sec for 4 hours gave 5.76 Ci of
165Dy(specific activity, 610mCi/mg Dy) with high
radionuclidic purity (>99.9%). 165Dy-MA was prepared in
a quantitative yield by reacting the aqueous solution
of 165Dy(NO3)3 with sodium borohydride solution in 0.2N
NaOH. Coulter particle analyzer exhibited mean particle
size of 2.6um (range 1~6um). Even though the 165Dy-MA
suspension in saline was stored at 37`C for 24hours of
autoclaved at 121`C for 30minytes, there was no
significant change in particle size and leakage problem
indicating the prepared 165Dy-MA is sufficiently
stable. In-vivo retention studies were carried out by
administering 165Dy-MA into the knee joing space of
normal rabbits. Gamma camera analysis showed high
retention in joing space of normal rabbits. Gamma
camera analysis showed high retention in joing space
even at 24 hours after administration (>99.9%) The ease
with which the 65Dy-MA can be made in the narow size
range and their high in vitro and vivo stability make
them attractive agents for radiation synovectomy. |
Keyword |
Dysprosium metallic macroaggregates, Radiation synovectomy, Rheumatoid arthritis |
Full text Article |
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