원저 : 진행성 핵상 마비에서의 국소 뇌혈류 ( Regional Cerebral Perfusion in Progressive Supranuclear Palsy ) () |
Author |
이원용(Won Yong Lee),이경한(Kyung Han Lee),이기형(Ki Hyeong Lee),윤병우(Byung Woo Yoon),이명철(Myung Chul Lee),이상복(Sang Bok Lee),전범석(Beom S . Jeon), |
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Affiliation |
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Abstract |
Progressive supranuclear palsy (PSP) is a parkinson-
plus syndrome characterized clinically by supranuclear
ophthalmoplegia, pseudobulbar palsy, axial rigidity,
bradykinesia, postural instability and dementia.
Presence of dementia and lack of cortical
histopathology suggest the derangement of cortical
function by pathological changes in subcortical
structures in PSP, which is supported by the pattern of
behavioral changes and measurement of brain metabolism
using positron emission tomography. This study was done
to examine whether there are specific changes of
regional cerebral perfusion in PSP and whether there is
a correlation between severity of motor abnorma- ility
and degree of changes in cerebral perfusion. We
measured regional cerebral perfusion indices in 5
cortical and 2 subcortical areas in 6 patients with a
clinical diagnosis of PSP and 6 healthy age and sex
matched controls using Tc-99m-HMPAO SPECT. Compared
with age and sex matched controls, only superior
frontal regional perfusion index was significantly
decreased in PSP (p〈0.05). There was no correlation
between the severity of the motor abnormility and any
of the regional cerebral perfusion indices (p〉0.05).
We affirm the previous reports that perfusion in
superior frontal cortex is decreased in PSP. Based on
our results that there was no correlation between
severity of motor abnormaility and cerebral perfusion
in the superior frontal cortex, nonmotoric symptoms
including dementia needs to be looked at whether there
is a correlation with the perfusion abnormility in
superior frontal cortex. |
Keyword |
Progressive supranuclear palsy, 99mTc-HMPAO SPECT, Regional cerebral perfusion index |
Full text Article |
28501622.pdf
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