원저 : 만성 신부전 환자에서 99mTc - HMDP 골신티그램상 섭취정도와 혈중 osteocalcin , 부갑상선 호르몬치와의 상관관계 ( 99mTc - HMDP Bone Uptake Quantification and Plasma Osteocalcin , PTH Levels in Hemodialysis Patients ) () |
Author |
김의녕(Euy Neyng Kim),손형선(Hyung Sun Sohn),방찬영(Chan Young Band),정수교(Soo Kyo Chung),김춘열(Choon Yul Kim),신경섭(Kyung Sub Shinn),박철휘(Chul Whee Park),장윤식(Yoon Sik Chang), |
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Affiliation |
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Abstract |
In this preliminary study, plasma osteocalcin, PTH
level and Tc-99m-HMDP (hydro- xymetylene diphosphonate)
bone uptake(BU) were measured in 14 patients with
chronic end-stage renal failure who were on maintenance
hemodialysis. The aim of this study was to determine
the difference of bone uptake between renal failure
patients and normal volunteers, and to determine the
correlation between bone uptake and osteocalcin a
sensitive and specific marker of osteoblastic activity
and PTH - a important hormone of bone metabolism. There
was a statistically significant increase in 180 minute
uptake in the patient group when compared to the normal
volunteers while there was no statistically significant
difference in 20 minute uptake. Plasma osteocalcin and
PTH levels were also significantly elevated compared to
normal values. But the correlation between osteocalcin,
PTH and 20 and 180 minute bone uptake was not
significant. In conclusion, our preliminary study
suggests that, in chronic renal failure patients, 180
minute Tc-99m-HMDP bone uptake is increased
significantly without direct correlation with serum
osteocalcin or PTH levels. It seems that further study
is needed to evaluate other unknown factors that may
influence the direct correlation between bone uptake
and plasma osteocalcin and PTH in patients with chronic
renal failure. |
Keyword |
Osteocalcin, PTH, 99mTc-HMDP, Chronic renal failure |
Full text Article |
28501761.pdf
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