원저 : Tungsten-188/Rhenium-188 발생기의 정도관리 ( Quality Control of Tungsten-188/Rhenium-188 Generator ) () |
Author |
장영수(Young Soo Chang),정재민(Jae Min Jeong),이동수(Dong Soo Lee),정준기(June Key Chung),이명철(Myung Chul Lee), |
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Affiliation |
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Abstract |
Purpose: For the purpose of using Re-188 as a
therapeutic radionuclide, we performed the quality
control of the W-188/Re-188 generation system.
Materials and Methods: Several quality control tests of
the Re-188 eluate from generator were carried out of
about 300 days. After elution of Re-188 with normal
saline (20 ml), chromatogram and gamma-ray spectrum of
Re-188 eluate were obtained. The presence of aluminum
which was derived from the elumina bed of the generator
was detected by using aluminum ion indicator kit. Re-
188 eluate was allowed to decay for several days, and
then W-188 breakthrough in the Re-188 eluate was
measured by detecting gamma-ray at 227 keV and 290 keV.
The pH and the pyrogenicity of the eluate were checked.
The Re-188 eluate from the generator was 67.4¡¾7.0%
of W-188 during 270 days, and it was hightest at third
day after previous elution. Radiochemical purity of Re-
188 eluate obtained from chromatogram was higher than
99%. Gamma-ray spectrum of Re-188 eluate showed a peak
at 155 keV. Aluminum ion and W-188 contamination were
not detected. The pH of Re-188 eluate was 3 and the
concentration yield was 85%. Conclusion: Our
experiments and results on quality control tests of Re-
188 eluate from W-188/Re-188 generator may be useful
for setting W-188/Re-188 generator in hospitals. |
Keyword |
W-188/Re-188 generator, Quality control, Radionuclide therapy |
Full text Article |
28502207.pdf
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