마이크로웨이브와 Sep-Pak 카트리지를 이용한 99mTc-ECD, MAG3, MIBI의 신속한 제조 및 정도관리 ( Rapid Preparation and Quality Control of 99mTc-ECD, MAG3 and MIBI using Microwave Heating and Sep-Pak Cartridges ) () |
Author |
오승준(Seung Jun Oh),문대혁(Dae Hyuk Moon),류진숙(Jin Sook Ryu),이희경(Hee Kyung Lee), |
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Affiliation |
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Abstract |
Purpose: We evaluated a rapid preparation procedures for the labeling and quality control of 99mTc-ECD, MAG3, and MIBI using microwave heating and Sep-Pak cartridges. Materials and Methods: 99mTc labeling of ECD, MAG3, and MIBI kit preparation was performed according to the package inserts with microwave heating modification. Heating time was 10-15 sec, and heating was performed with 3 mm plastic bottle with screw cap to prevent radiation contamination. Labeling efficiency was obtained with C18 or Alumina N Sep-Pak cartridges. Results: The radiochemical purity of 93∼96% for 99mTc-ECD and 95∼99% for 99mTc-MIBI was obtained using Alumina N Sep-Pak cartridge. The optimum irradiation time of microwave method for 3 ml 99mTc-labeled radiopharmaceutical solution was 10 sec for 99mTc-ECD and 99mTc-MIBI, and 15 sec for 99mTc-MAG3. The results of quality control data with Sep-Pak cartridges were well correlated with TLC method. The total preparation time of these radiopharmcaeuticals was 5∼6 min including quality control procedure. Conclusion: This study demonstrates that radiopharmaceuticals preparation by microwave heating and quality control by Sep-Pak cartridges can be efficiently utilized as an alternative to the recommended method by manufacturer's manual. (Korean J Nucl Med 1999;33:430-8) |
Keyword |
99mTc-ECD, 99mTc-MIBI, 99mTc-MAG3, Microwave heating, Sep-Pak cartridge, Quality control |
Full text Article |
28502425.pdf
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