Author |
박기한(Ki Han Park),김창근(Chang Guhn Kim),윤권하(Kwon-Ha Yoon),최시성(See Sung Choi),이종덕(Jong Deuk Lee),이광만(Kwang Man Lee),원종진(Jong Jin Won), |
Abstract |
Purpose: The purpose of this study was to evaluate the
diagnostic usefulness of scintimammography performed
with Tc-99m tetrofosmin in the detection of primary
breast cancer. Materials and Methods: Sixty-one
patients underwent Tc-99m tetrofosmin
scintimammography, plain-filrn mammography and
ultrasonography. After intravenous injection of Tc-99m
tetrofosmin (740 MBq), prone lateral and anterior
scintimammograms were obtained. Scintimammogram was
visually interpreted as positive, probably positive,
probably negative and negative for malignancy. The
tumor to background count ratio (T/B) was measured at 5
minutes and 1 hour. Plain-film mammogram was
interprcted as one of 5 categories. Final diagnosis was
achieved by surgical histology (58/61) or fine needle
aspiration (3/61). Of 61 patients, 44 had cancer and 17
had benign lesion. Tumor size of malignant and benign
lesions on ultrasonogram were 2.51+-1.30 cm (range 1-8
cm), 2.50+-1.35 cm (range 0.96-6 cm), respectively.
Results: The sensitivity of plain-film mammography was
88.6%, specificity 58.8%, positive predictive value
84.7%, and negative predictive value 66.7%. The
sensitivity of Tc-99m tetrofosmin scintimammography was
90.9%; specificity, 88.2%; positive predictive value,
94.9%; negative predictive value, 78.9%. Of 25 patients
with indeterminate degree of suspicion for malignancy
on plain-film mammogram, 23 were correctly diagnosed by
scintimamography. The T/B at 5 minutes and 1 hour were
3.78+-2.21, 3.25+-1.80 respectively. The T/B was
decreased significantly at 1 hour (p<0.001).
Conclusion: Tc-99rn tetrofosrnin scintimammography was
useful diagnostic procedure in the detection of primary
breast cancer, especially in patients with
indeterminate degree of suspicion for malignancy on
plain-film mammogram. (Korean J Nucl Med 1999;3.3:452-
460)
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