혈액 종양 질환에서 항과립구항체 골수 스캔을 이용한 중심 골수와 말초 골수 분포의 분석 (Central and Peripheral Distribution of Bone Marrow on Bone Marrow Scintigraphy with Antigranulocytic Antibody in Hematologic Malignancy) |
Author |
강도영,이재태,손상균,이규보, |
Do-Young Kang, M.D., Jaetae Lee, M.D., Sang Kyun Sohn, M.D. and Kyu Bo Lee, M.D. |
Affiliation |
동아대학교 의과대학 핵의학교실, 경북대학교 의과대학 핵의학교실 Department of Nuclear Medicine, Dong-A University College of Medicine, Busan, Korea, Department of Nuclear Medicine, Kyungpook University School of Medicine, Taegu, Korea |
Abstract |
Purpose: Bone marrow scintigraphy has been used to evaluate the status of bone marrow in various
hematologic disorders. We have analyzed the peripheral distribution pattern and central uptake ratio of
bone marrow using anti-NCA-95 monoclonal antibody and the their correlation in patients with various
hematologic malignancy. Materials and Methods: Bone marrow immunoscintigraphy was performed using
Tc-99m anti-granulocyte monoclonal mouse antibody BW 250/183. Fifty patients were classified into four
groups; 11 with acute myelogenous leukemia, 12 with acute lymphocytic leukemia, 15 with lymphoma and
12 with myelodysplastic syndrome. The extension of peripheral bone marrow was categorized into four
grades: I, II, III and IV. The activity of central bone marrow was expressed as sacroiliac uptake ratio.
Results: The patient's number was 4 in grade I, 27 in grade II, 15 in grade III and 4 in grade IV according
to extension of peripheral bone marrow. The extension of peripheral bone marrow was marked (58% in
grade III and IV) in myelodysplastic syndrome and acute lymphocytic leukemia and mild (93% in grade I
and II) in lymphoma. Sacroiliac uptake ratio was highest (8.5¡¾4.0) in myelodysplastic syndrome and lowest
(5.9¡¾3.6) in acute myelogenous leukemia, but not significantly different among four patient groups (p>0.05).
Sacroiliac uptake ratio of whole patients was significantly different among four grades (p=0.003), but there
was not correlated between grade of peripheral bone marrow and sacroiliac uptake ratio (r=0.05).
Conclusion: The pattern of peripheral bone marrow extension and activity of central hemopoietic marrow
were not specific to the disease entities. Response of hemopoietic bone marrow may be evaluated on both
peripheral and central bone marrow in patients with hematologic malignancy. (Korean J Nucl Med
2002;36;298-305) |
Keyword |
Bone marrow scintigraphy, Hematologic malignancy, Tc-99m antiNCA-95 |
Full text Article |
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