홍역 후 발병된 급성 뇌염 진단시 Tc-99m ECD 뇌혈류 SPECT의 임상적 유용성 (The Clinical Usefulness of Tc-99m ECD Brain SPECT in Acute Measles Encephalitis) |
Author |
임석태,손명희, |
Seok Tae Lim, M.D., and Myung-Hee Sohn, M.D. |
Affiliation |
전북대학교 의과대학 핵의학교실, 의과학연구소, 임상의학연구소 Departments of Nuclear Medicine, Institute for Medical Sciences, and Research Institute of Clinical Medicine Chonbuk National University Medical School, Chonju, Korea |
Abstract |
Purpose:Since the prognosis of measles encephalitis is poor, early diagnosis and proper management are
very important to improve clinical outcomes. We compared Tc-99m ECD brain SPECT (SPECT) with MR
imaging (MRI) for the detection of acute measles encephalitis. Materials and Methods:Eleven patients
(M:F=4:7, age range 18 months-14 yrs) with acute measles encephalitis were enrolled in this studies. All
of them underwent both MRI and SPECT. The results of SPECT were scored from 0 (normal) to 3 (most
severe defect) according to perfusion state. We compared two image modalities for the detection of brain
abnormality in acute measles encephalitis. Results:Seven of 11 patients (63.6%) revealed high signal
intensity in the white matter on T2WI of MRI, on the other hand all patients (100%) showed hypoperfusion
on SPECT. Severe perfusion deficits above score 2 were located with decreasing frequencies in the frontal
lobe (81.8%), temporal lobe (72.7%), occipital lobe (27.3%), basal ganglia (27.3%), and parietal lobe (9.1%).
Conclusion:We conclude that SPECT is more useful than MRI for the detection of brain involvement in
patients with acute measles encephalitis. |
Keyword |
Acute measles encephalitis, brain SPECT, Tc-99m ECD |
Full text Article |
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