I-123 IPT SPECT를 이용한 주의력결핍 과잉행동장애 아동에서의 methylphenidate 투여 전후의 기저 신경절 도파민 운반체 밀도 변화 측정 (Dopamine Transporter Density of the Basal Ganglia in Children with Attention Deficit Hyperactivity Disorder Assessed with I-123 IPT PECT) |
Author |
류원기,김태훈,유영훈,윤미진,천근아,지대윤,김종호,최태현,이종두, |
Won Gee Ryu, M.D., Tae Hoon Kim, MD., Young Hoon Ryu, M.D., Keun Ah Cheon, M.D., Mijin Yun, M.D., Dae Yoon Chi, Ph.D., Jong Ho Kim, M.D., Tae Hyun Choi, M.Sc, Jong, Doo Lee, M.D. |
Affiliation |
연세대학교 의과대학 진단방사선과학 교실,정신과학 교실,인하대학교 화학과,가천대학교 의과대학 핵의학과 교실 Department of Diagnostic Radiology, Department of Psychiatry, College of Medicine, Yonsei University, Department of Chemistry, University, Department of Nuclear Medicine, Medical School. |
Abstract |
Purpose:Attention deficit hyperactivity disorder (ADHD) has been known as psychiatric disorder in
childhood associated with dopamine dysregulation. In present study, we investigated changes in dopamine
transporter (DAT) density of the basal ganglias using I-123 N-(3-iodopropen-2-yl) -2-carbomethoxy
-3beta-(4-chlorophenyl) tropane [I-123 IPT] SPECT in children with ADHD before and after
methylphenidate treatment. Materials and Method:Nine drug-naive children with ADHD and seven
normal children were included in the study. We performed brain SPECT two hours after the intravenous
administration of I-123 IPT and made both quantitative and qualitative analyses using the obtained SPECT
data, which were reconstructed for the assessment of specific/nonspecific DAT binding ratios in the basal
ganglia. All children with ADHD reperformed [123I]IPT SPECT after treatment with methylphenidate
(0.7mg/kg/d) during about 8 weeks. SPECT data reconstructed for the assessment of specific/nonspecific
DAT binding ratio of the basal ganglia were compared between before and after treatment methylphenidate.
We investigated correlation between the change of ADHD symptom severity assessed with ADHD rating
scale-IV and specific/nonspecific DAT binding ratio of basal ganglia. Results:Children with ADHD had a
significantly greater specific/nonspecific DAT binding ratio of the basal ganglia comparing to normal children
(Right:z = 2.057, p = 0.041;Left:z = 2.096, p = 0.032). Under treatment with methylphenidate in all
children with ADHD, specific/nonspecific DAT binding ratio of both basal ganglia decreased significantly
greater than before treatment with methylphenidate (Right:t = 3.239, p = 0.018;Left:t = 3.133, p = 0.020).
However, no significant correlation between the change of ADHD symptom severity scores and
specific/nonspecific DAT binding ratio of the basal ganglia were found. Conclusions:These findings
support the complex dysregulation of the dopaminergic neurotransmitter system in children with ADHD. |
Keyword |
I-123 IPT, SPECT, Attention Deficit Hyperactivity disorder, Basal ganglia, Dopamine |
Full text Article |
3804235.pdf
|
|
|