버섯 중독 환자에서의 99mTc-galactosyl human serum albumin (GSA) scintigraphy 소견:간초음파 소견과의 비교 (99mTc-DTPA Galactosyl Human Serum Albumin Scintigraphy in Mushiroom Poisoning Patient:Comparison with Liver Ultrasonography) |
Author |
정신영, 이재태, 배진호, 천경아, 안병철, 강영모, 정재민, 이규보, |
Shin Young Jeong, MD, Jeatae Lee, MD, Jin Ho Bae MD, Kyung Ah Chun, MD, Byeong-Cheol Ahn, MD, Young Mo Kang, MD1, Jae Min Jeong, PhD2 and Kyu Bo Lee, MD |
Affiliation |
경북대학교 의과대학 핵의학교실, 내과학교실 서울대학교 의과대학 핵의학교실 Department of Nuclear Medicine, Internal Medicine Kyungpook National University School of Medicine, Daegu, Korea Department of Nuclear Medicine, Seoul University Hospital, Seoul, Korea |
Abstract |
99mTc-galactosyl human serum albumin (Tc-GSA) is a radiopharmaceutical that binds to asialoglycoprotein
receptors, which are specifically present in the hepatocyte membrane. Because these receptors are
decreased in hepatic parenchymal damage, the degree of Tc-GSA accumulation in the liver correlates with
findings of liver function test. Hepatic images were performed with Tc-GSA in patients with acute hepatic
dysfunction by Amantia Subjunquillea poisoning, and compared with these of liver ultrasonography (USG).
Tc-GSA (185 MBq, 3 mg of GSA) was injected intravenously, and dynamic images were recorded for 30
minutes. Time-activity curves for the heart and liver were generated from regions of interest for the whole
liver and precordium. Degree of hepatic uptake and clearance rate of Tc-GSA were generated by visual
interpretation and semiquantitative analysis parameters (receptor index:LHL15 and index of blood
clearance:HH15). Visual assessment of GSA scintigraphy revealed mildly decreased liver uptake in all of
subjects. The mean LHL15 and HH15 were 0.886 and 0.621, graded as mild dysfunction in 2, and mild to
moderate dysfunction in 1 subject. In contrast, liver USG showed no remarkable changes of hepatic
parenchyme. Tc-GSA scintigraphy was considered as a useful imaging modality in the assessment of the
hepatic dysfunction. |
Keyword |
99mTc-DTPA galactosyl human serum albumin, liver ultrasonography, Amanita subjunquillea poisoning, liver function |
Full text Article |
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