Re-188이 표지된 황 교질(Sulfur Colloid)/리피오돌(Lipiodol)의 제조와 생체내 분포 (Preparation and Biodistribution of Re-188-Sulfur Colloid Suspension in Lipiodol) |
Author |
김영주,정재민,김석기,손미원,이동수,정준기,이명철, |
Young Ju Kim, B.S., Jae Min Jeong, Ph.D., Seok Ki Kim, M.D., Miwon Son, Ph.D., Dong Soo Lee, M.D., June-Key Chung, M.D., Myung Chul Lee, M.D. |
Affiliation |
서울대학교 의과대학 핵의학교실, 국립 암센터 핵의학과, 동아제약(주) 연구소 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea;Department of Nuclear Medicine, National Cancer Center, Korea, Research Laboratories, Dong-A Pharm. Co., Ltd. |
Abstract |
Lipiodol is used for targeting liver cancers by administrating through the hepatic artery. In the
present study, feasibility of Re-188-sulfur colloid suspension in lipiodol as a liver cancer targeting agent was
investigated. Materials and Methods: Re-188-sulfur colloid was prepared, harvested by centrifugation,
washed with organic solvent and then suspended into lipiodol. Biodistribution of Re-188-sulfur colloid in
normal saline and its suspension in lipiodol in mice after 1 hr of injection through the tail vein were
investigated. Biodistribution and autoradiography of tumor-bearing liver was acquired after 5 min
post-injection into left ventricle of the tumor-inoculated rats. Results: After 1 hr of injection with
Re-188-sulfur colloid suspensiob in lipiodol through the tail vein in normal mice (n=3), the uptakes in the
liver and lung were 5.2±0.7 and 91.0±1.7% ID/organ, respectively. After 5 min of injection with
Re-188-sulfur colloid suspention in lipiodol through the left ventricle in the tumor-inoculated rats (n=4),
uptakes in the normal liver, hepatoma, and lung were 0.41±0.28, 1.88±1.57, and 1.65±1.54% ID/organ,
respectively. And autoradiography of hepatoma showed increased uptake than normal liver tissues.
Conclusion: Re-188-sulfur colloid suspension in lipiodol injected through the artery shows higher uptake in
the hepatoma than normal liver tissue that indicates the feasibility as a new radiopharmaceutical for therapy
of hepatoma. |
Keyword |
Re-188-Sulfur Colloid, Lipiodol, Hepatoma, Biodistribution |
Full text Article |
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