게이트 심근 SPECT를 이용한 좌심실의 국소탄성률 평가방법 개발 및 재현성 평가 (Development of Evaluation Method of Regional Contractility of Left Ventricle Using Gated Myocardial SPECT and Assessment of Reproducibility) |
Author |
이병일,이동수,이재성,강원준,정준기,이명철,최흥국, |
Byeong Il Lee, Dong Soo Lee, Jae Sung Lee, Won Jun Knag, June-Key Chung,Myung Chul Lee, Heung Kook Choi |
Affiliation |
인제대학교 정보컴퓨터공학부,서울대학교의과대학 핵의학교실 Department of Information & Computer Engineering, Inje University, Kimhae, Korea Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea |
Abstract |
Purpose: Regional contractility can be calculated using the regional volume change of left ventricle
measured by gated myocardial SPECT image and curve of central artery pressure obtained from radial
artery pressure data. In this study, a program to obtain the regional contractility was developed, and
reproducibility of regional contractility measurement was assessed. Materials and Methods: Seven patients
(male:female=5:2, 58±11.9 years) with coronary artery diseases underwent gated Tc-99m MIBI myocardial
SPECT twice without delay between two scans. Regional volume change of left ventricle was estimated
using CSA (Cardiac SPECT Analyzer) software developed in this study. Regional contractility was iteratively
estimated from the time-elastance curve obtained using the time-pressure curve and regional time-volume
curve. Reproducibility of regional contractility measurement assessed by comparing the contractility values
measured twice from the same SPECT data and by comparing those measured from the pair of SPECT
data obtained from a same patient. Results: Measured regional contractility was 3.36 ± 3.38 ㎜Hg/mL
using 15-segment model, 3.16 ± 2.25 ㎜Hg/mL using 7-segment model, and 3.11 ± 2.57 ㎜Hg/mL using
5-segment model. The harmonic average of regional contractility value was almost identical to the global
contractility. Correlation coefficient of regional contractility values measured twice from the same data was
greater than 0.97 for all models, and two standard deviations of contractility difference on Bland Altman plot
were 1.5%, 1.0%, and 0.9% for 15-, 7-, and 5-segment models, respectively. Correlation coefficient of
regional contractility values measured from the pair of SPECT data obtained from a same patient was
greater than 0.95 for all models, and two standard deviations on Bland Altman plot were 2.2%, 1.0%, and
1.2%. Conclusion: Regional contractility of left ventricle measured using developed software in this study
was reproducible. Regional contractility of left ventricle will be a new useful index for myocardial function
after analysis of the clinical data. |
Keyword |
gated myocardial SPECT, contractility, regional Emax |
Full text Article |
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