Author |
박성기(Sung Ki Park),문대혁(Dae Hyuk Moon),이명철(Myung Chul Lee),조보연(Bo Youn Cho),김병국(Byoung Kook Kim),김노경(Noe Kyeong Kim),고창순(Chang Soon Koh),이문호(Mun Ho Lee), |
Abstract |
To evaluate the clinical significance of serum tissue
polypeptide antigen (TPA) levels in patients with
malignancy, serum TPA levels were measured by
radioimmunoassay in 49 normal controls, 9 patients of
postoperative colon cancer without recurrence and 68
patients with various untreated malignancy, who visited
Seoul National University Hospital from February, 1983
to September, 1983. The results were as follows; 1)
Serum TPA levels in 49 normal controls were in the
range of 22-135U/L (74±28U/L, mean±S.D.). There was
no sex or age difference. Normal upper limit of serum
TPA was defined as 130U/L (mean+2 S.D.). 2) Serum TPA
levels in 68 patients with various untreated malignancy
(stomach cancer 33 cases, colon cancer 11 cases, lung
cancer 10 cases, primary liver. cancer 9 cases and
metastatic cancer of unknown primary site 5 cases) were
in the range of 10-800U/L (189±170U/L, mean±S.D.) and
significantly elevated, compared with those of normal
controls (p〈0.005). 3) The sensitivities of serum TPA
in various untreated malignancy were 39% in stomach
cancer, 55% in colon cancer, 50% in lung cancer, 67% in
primary liver cancer and 80% in metastatic cancer of
unknown primary site respectively. 4) The sensitivities
of serum TEA related to resectability in stomach and
colon cancer were 32% in resectable stomach cancer, 50%
in unresectable stomach cancer, 29% in resectable colon
cancer and 100% in unresectable colon cancer
respectively. 5) The mean value of serum TPA levels in
9 patients of postoperative colon cancer without
recurrence was 70±39U/L and significantly decreased,
compared with that of untreated colon cancer,
180±150U/L (p〈0.05). 6) In patients with stomach or
colon cancer, there was no significant correlation
between serum TPA and serum CEA levels, but
simultaneous measurement of serum TPA and serum CEA
levels increased sensitivieties. From above results, we
concluded that serum TPA level is a useful indicator
reflecting tumor actiivity and responses to anticancer
treatment in patients with malignan |