Abstract |
Tumor localizing properties of 67Ga citrate and 169Yb
citrate were studies with sarcoma 180 bearing mice. To
compare precisely the accumulation of 67Ga citrate and
169Yb citrate in tumor tissue itself, 67Ga and 169Yb
were administered simultaneously as a mixture of same
chemical form of citrate. The yield of 169Yb labeled
citrated and the of radiopharmaceuticals purity was
identified more than 90% by chromatography on silica
gel plates. 67Ga and 169Yb were injected into mice and
the mice were killed at 3, 24, and 48 hours following
intraperitoneal injection of the radiopharmaceuticals.
The retention value of 67Ga and 169Yb in tumor was
similar but they differ from each other markedly in
normal tissue distribution. 169Yb citrate is cleared up
from blood more rapidly than 67Ga citrate, and a high
tumor to blood ratio is achieved shortly after
injection. |