Author |
김상은(Sang Eun Kim),이동수(Dong Soo Lee),정준기(June Key Chung),이명철(Myung Chul Lee),고창순(Chang Soon Koh),조수철(Soo Churl Cho),홍승봉(Seung Bong Hong),윤병우(Byung Woo Yoon),노재규(Jae Kyu Roh),명호진(Ho Jin Myung), |
Abstract |
Regional cerebral blood flow (rCBF) was evaluated in 12
children ranging in age from 2.7 to 10.0 yr using
99mTc-HMPAO SPECT. For quantitative analysis, 13 pairs
of homologous regions of interest (ROIs) were created
on three attenuation-corrected 18,8 mm thick transverse
slices matching the cerebral cortical regions, deep
gray matter, cerebellar hemisphere, and vascular
territories, and the semiquantitative indices including
"right to left ratio [(mean countjvoxel of homologous
right ROI) /(mean count/voxel of homologous left ROI) ]
and regional index "(RI) [ (mean count/voxel of a ROI)
/(rnean count/voxel of all ROIs of each hemisphere)]
were calculated. Mean values of right to left ratios of
homologous tegions ranged frorn 0.984 to 1.028 in
children under 5 yr (group 1) and from 0.982 to 1.012
in children between 5 and 10 yr (group 2), and the mean
value +-2 S.D. for each region did not exceed 11%. and
12% in group 1 and group 2, respective]y. There were no
statis- tically significant differences between the RIs
of the homologous right and left regions. Significant
differences of RIs were found both between vascular
regions (p<0,0005 for goup 1, and p=0,0001 for goup 2)
and between regions of cerebral cortices (p<0,0005 for
group 1, and p<0,005 for group 2) with a relatively
high value in the occipital cortex and the Iower values
in the r.erebellum and deep gray matter among the
regions of cerebral cortices in both groups. There were
no significant differences between the Rls of
corresponding regions of group 1 and group 2, except a
significantly higher value of right deep gray matter in
group 2 than in group 1(p=0.0301). The RIs of the
superior frontal cortex and deep gray matter showed to
be positively correlated with age (superior frontal
cortex; right: rs=0.5254, p =0.0814, left: rs=0.5919,
p=0.0496/deep gray matter; right: rs=0.8246, p=0.0062,
left: rs=0.6266, p=0,0377). The results suggest that
the rCBF pattern of children approaches that of adults
in an occipito-rostraJ direction. This time course of
rCBF changes is in agreement with behavioral,
neurophysiological, and anatomical alterations known to
occur in the developing brain. |