Abstract |
Chitosan is known to be one of the natural chelating
agents. It is derived from chitin which is a cellu1ose-
like biopolymer distributed widely in nature,
especially in shellfish, insects, fungi, and yeast.
There are two forms of chitosans, water solube and
insoluble. The purpose of the present study is to
investigate whether water soluble chitosan can be
applied to reduce the bioabailability of radiostrontium
in foods. We compared the effect of water soluble and
insoluble chitosans on the absorption of ingested
radiostrontium(85Sr). Three percent water soluble and
insoluble chitosan solutions were given ora1ly, and
immediately after 85SrCl2 (0.2 μCi) was administered
to rats using a orogastric tube. In one group water
solube chitosan solution was given for additional 4
days. And in control group no chitosan was given. Each
group consisted of 6 rats. The whole-body retention of
85Sr, determined by in vivo counting method, was lower
in water soluble chitosan group than that of water
insoluble chitosan group and that of control. Urinary
excrecion of 85Sr in chitosan-treated rats was higher
than that of control. And 5 day ingested group of water
soluble chitosan showed least whole retention of 85Sr.
In conclusion water soluble chitosan was more effective
in reducing bioavailability of ingested radiostrontium
in the gastronintestinal tract than insoluble chitosan. |