Colloid uptake in various hepatic conditions such as focal nodular hyperplasia, regenerating noduies in the cirrhotic liver, hamartoma, hemangioma and rarely hepatoma has been documented. Extrahepatic tumors may show colloid uptake and they include splenic hemangioma, malignant fibrous histiocytoma, breast carcinoma and Kaposis sarcoma. The mechanism of colloid uptake in those lesions is associated with phagocytic activity in or around the tumors. We report a pancreas islet cell tumor that showed colloid uptake on 99mTc- phytate liver scan without histologic evidence of phagocytosis by tumor cells or infiltration of phagocytes in the tumor. Microscopically the tumor was highly vascular and showed diffuse hemorrhage throughtout the turnor. We postulated that extravasation of the colloid into the tumor insterstitium caused nonspecifi colloid uptake in this tumor. It is expected that hemorrhagic tumor may show nonsper.ific colloid uptake without phagocytosis in or about the lesion.