원저 : 국소뇌허혈에서 NMDA 수용체 길항제가 국소 뇌포도당 대사율에 미치는 영향 ( Effect of NMDA Receptor Antagonist on Local Cerebral Glucose Metabolic Rate in Focal Cerebral Ischemia ) () |
Author |
김상은(Sang Eun Kim),홍승봉(Seung Bong Hong),윤병우(Byung Woo Yoon),배상균(Sang Kyun Bae),최창운(Chang Woon Choi),이동수(Dong Soo Lee),정준기(June Key Chung),노재규(Jae Kyu Roh),이명철(Myung Chul Lee),고창순(Chang Soon Koh), |
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Affiliation |
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Abstract |
There has recently been increasing interest in the use
of NMDA receptor antagonists as potential
neuroprotective agents for the treatment of ischemic
stroke. To evaluate the neuropro- tective effect of the
selective non-competitive NMDA receptor antagonist MK-
801 in focal cerebral ischemia, local cerebral glucose
utilization (1CGU) was examined in 15 neuroanatomically
discrete regions of the conscious rat brain using the
2-deoxy-D[14C]glucose quantitative autoradiographic
technique 24 hr after left middle cerebral artery
occlusion (MCAO). Animals received MK-801 (5 mg/kg
i.v.) or saline vehicle before (20-30 min) or after (30
min) MCAO. Both pretreatment and posttreatment of MK-
801 increased occluded/non-occluded 1CGU ratio in 7 and
5 of the 15 regions measured, respectively(most notably
in cortical structures). Following MK-801 pretreatment,
there was evidence of widespread increases in 1CCPU not
only in the non-occluded hemisphere (12 of the 15 areas
studied) but also in the occluded hemisphere (13 of the
15 areas studied), while MK-801 postreatment did not
significantly increase 1CGU both in the normal and
occluded hemispheres. These data indicate that MK-801
has a neuroprotective effect in focal cerebral ischemia
and demonstrate that MK-801 provides widespread
alterations of glucose utilization in conscious
animals. |
Keyword |
NMDA receptor, MK-801, Cerebral glucose utilization, Focal cerebral ischemia, Autoradiography |
Full text Article |
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