원저 : 악성 갈색세포종 및 갑상선수질암의 131I - MIBG 을 이용한 치료 ( 131I - MIBG Therapy in Malignant Pheochromocytoma and Medullary Thyroid Carcinoma ) () |
Author |
윤종길(Jong Kil Yoon),류백렬(Baek Yeol Ryoo),이창희(Chang Hee Lee),정상훈(Sang Hoon Jeong),천영국(Young Kug Cheon),최창운(Chang Woon Choi),임상무(Sang Moo Lim),홍성운(Sung Woon Hong), |
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Affiliation |
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Abstract |
131I-metaiodobenzylguanidine(MIBG) has been used for
the diagnosis and treatment of neural crest tumors. We
report our experience with this agent in 8 patients[l
multiple endocrine neoplasia(MEN) type IIb; 2 malignant
pheochromocytoma; 5 medullary thyroid carcinoma(MTC)].
The therapeutic procedure consisted of 30-200 mCi of
131I-MIBG administered by slow I.V. infusion, given at
3-6 months intervals. Cummulative activity ranged from
150 mCi to 410 mCi, in 1 to 4 courses. 131I-MIBG
therapy resulted in significant disease free interval
in 1 malignant pheochromocytoma(no measurable
lesion)after sugery; complete hormonal and tumoral
response in 2 MTC(1 MEN IIb); stable disease in 1
recurred pheochromocytoma(MEN IIb); stable disease but
symptomatic improvement in 1 MTC; progressive disease
in 1 malignant pheochromocytoma and 2 MTC. The patients
who showed progression appeared to have large
inoperable tumors or postoperative remnant tumors. |
Keyword |
131I-MIBC Therapy, Pheochromocytoma, Medullary Thyroid Caroinoma |
Full text Article |
28501543.pdf
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