F-18 FDG PET/CT에서 미만성 골수 섭취증가: 골수 생검 및 혈액 검사와의 연관성 비교 (Diffuse Hypermetabolism at Bone Marrow in F-18 FDG PET/CT: Correlation with Bone Marrow Biopsy and Complete Blood Cell Counts) |
Author |
강윤희, 임석태, 정영진, 김동욱, 정환정, 손명희, |
Yun-Hee Kang, Seok Tae Lim, Young Jin Jeong, Dong Wook Kim, Hwan-Jeong Jeong, Myung-Hee Sohn |
Affiliation |
전북대학교 의학전문대학원 핵의학교실1, 사이클로트론연구소2, 임상의학연구소3 1Department of Nuclear Medicine, 2Cyclotron Research Center, and 3Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea |
Abstract |
Purpose: Increased FDG uptake in the bone marrow has been reported in patients taking erythropoietin or granulocyte-colony stimulating factor (G-CSF). The aim of this study is to investigate the correlation between F-18 FDG uptake in the bone marrow and bone marrow finding, hematological parameters. Materials and Methods: Twenty patients who had diffuse FDG uptake at the bone marrow and received hematological examinations, bone marrow biopsy within 10 days before or after PET/CT were enrolled in this study. Among them, 11 patients were excluded; 4 patients received G-CSF or erythropoietin before PET/CT. Seven patients showed definite pathology in a bone marrow biopsy. The parameters included the measurement of WBC, hemoglobin, platelet and cellularity of the bone marrow. Results: Bone marrow FDG uptake was correlated with a low hemoglobin but not WBC, platelet. Histopathologic findings in marrow biopsies were various: normal finding (n=3), hyperplasia of granulocytic cells (n=2), eosinophilic hyperplasia (n=1), reactive lymphoid nodules (n=1), hypercelluar marrow (n=1), hypocelluar marrow (n=1). All patients except two, showed normal marrow celluarity. Conclusion: FDG uptake by bone marrow correlated with anemia but not WBC, platelet, bone marrow cellularity. (Nucl Med Mol Imaging 2009;43(1):35-39) |
Keyword |
Bone marrow, PET/CT, bone marrow biopsy, complete blood cell counts, FDG |
Full text Article |
4301035039.pdf
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