대장암 치료 후 추적 검사로서 F-18 FDG PET/CT의 역할: 혈청 CEA, CA 19-9 및 Computed Tomography와의 진단 성능 비교 (Diagnostic Role of F-18 FDG PET/CT in the Follow-up of Patients with Colorectal Cancer: Comparison with Serum CEA, CA 19-9 Levels and Computed Tomography) |
Author |
강성민1, 송봉일1, 이홍제1, 서지형1, 이상우1, 유정수1, 안병철1, 이재태1, 최규석2, 전수한2, |
Sungmin Kang, M.D.1, Bong Il Song, M.D.1, Hong-Je Lee, M.D.1, Ji-Hyoung Seo, M.D.1, Sang-Woo Lee, M.D.1, Jeongsoo Yoo, Ph.D.1, Byeong-Cheol Ahn, M.D.1, Jaetae Lee, M.D.1,Kyusuk Choi, M.D.2, and SooHan Jun, M.D.2 |
Affiliation |
경북대학교 의과대학 핵의학교실1, 외과학교실2 Department of 1Nuclear Medicine and 2Surgery, Kyungpook National University Hospital, Daegu, Korea. |
Abstract |
Purpose: Early detection of recurrence is an important factor for long term survival of patients with colorectal cancer. Measurement of serum levels of CEA, CA 19-9, CT and PET/CT has been commonly used in the postoperative surveillance of colorectal cancer. The purpose of this study was to compare the diagnostic ability of PET/CT, tumor marker and CT for recurrence in colorectal cancer patients after treatment. Materials and Methods: F-18 FDG PET/CT imaging was performed in 189 colorectal cancer patients who underwent curative surgical resection and/or chemotherapy. Measurement of serum levels of CEA, CA 19-9 and CT imaging were performed within 2 months of PET/CT examination. Final diagnosis of recurrence was made by biopsy, radiologic studies or clinical follow-up for 6 months after each study. Results: Overall sensitivity, specificity of PET/CT was 94.7%, 91.1%, while those of serum CEA were 44.7% and 97.3%, respectively. Sensitivity and specificity were 94.2%, 90.4% for PET/CT and better than those of combined CEA and CA 19-9 measurement (52.1%, 88.5%) in 174 patients measured available both CEA and CA 19-9 data. In 115 patients with both tumor markers and CT images available, PET/CT showed similar sensitivity but higher specificity (92.9%, 91.3%) compared to combination of tumor markers and CT images (92.9%, 74.1%). Conclusion: PET/CT was superior for detection of recurred colorectal cancer patients compared with both CEA, CA 19-9, and even with combination of both tumor markers and CT. Therefore PET/CT could be used as a routine surveillance examination to detect recurrence or metastasis of colorectal cancer. (Nucl Med Mol Imaging 2009;43(2):120-128)
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Keyword |
Colorectal cancer, F-18 FDG PET/CT, carcinoembryonic antigen, carbohydrate antigen 19-9, computed tomography, recurrence |
Full text Article |
06강성민.pdf
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