방사선치료 반응도 예측을 위한 예비 연구: [18F]FDG PET와의 비교 (Pilot Study for the Prediction of Response to Radiotherapy Using [18F]Fluorothymidine PET in Nasopharyngeal Cancer: Comparison with [18F]FDG PET) |
Author |
백소라1, 채선영1, 김혜옥1, 이상욱2, 오승준1, 임기천1, 문대혁1, 김재승1, 류진숙1, |
Sora Baek, M.D.1, Sun-Young Chae, M.D.1, Hye-Ok Kim, M.D.1, Sang-Wook Lee, M.D.2, Seung Jun Oh, Ph.D.1, Ki Chun Im, Ph.D.1, Dae Hyuk Moon, M.D.1, Jae Seung Kim, M.D.1, and Jin-Sook Ryu, M.D.1 |
Affiliation |
울산대학교 의과대학 서울아산병원 핵의학과1, 방사선 종양학과2 Departments of 1Nuclear Medicine and 2Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea |
Abstract |
Purpose: This study was performed to know
whether [18F]Fluorothymidine (FLT) positron emission
tomography (PET) can be used to monitor early response
to radiotherapy in comparison with
[18F]Fluorodeoxyglucose (FDG) PET, and to establish the
optimal imaging time for prediction of therapy
response. Materials and Methods: Two patients
with nasopharyngeal cancer underwent serial FLT PET and
FDG PET before and during radiotherapy. Three on-
treatment FLT and FDG PET scans were performed on 1
week, 2 weeks and 3 weeks (at each time of 10 Gy, 20 Gy
and 30 Gy delivered). The peak standardized uptake
values (SUVpeak) of primary tumors were measured on FLT
and FDG PET. Then, percent changes of SUVpeak after
therapy were calculated. Results: In two
patients, baseline values of SUVpeak on FDT PET were
higher than those on FLT PET (FLT vs FDG; 3.7 vs 5.0,
and 5.7 vs 15.0). In patient 1, FLT SUVpeak showed 78%,
78% and 84% of decrease on 1 week, 2 and 3 weeks after
treatment, whereas FDG SUVpeak showed 18%, 52% and 66%
of decrease, respectively. In patient 2, FLT SUVpeak
showed 75%, 75% and 68% of decrease, whereas FDG
SUVpeak showed 51%, 49% and 58% of decrease,
respectively. Both patients reached to complete
remission after radiotherapy. Conclusion: After
radiotherapy, the decrease of FLT tumor uptake preceded
the decrease of FDG tumor uptake in patients with
nasopharyngeal cancer, and 1 week after therapy may be
appropriate time for the assessment of early response.
FLT PET might be more useful than FDG PET for
monitoring early response to radiotherapy. |
Keyword |
[18F]Fluorothymidine , [18F]Fluorodeoxyglucose, PET, nasopharyngeal cancer, radiation therapy |
Full text Article |
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